Drug Name Norvasc

Clofazimine is a dye with bactericidal activity against M. leprae and antiinflammatory properties. It is given orally, but is incompletely absorbed. Because of its high lipophilicity, it accumulates in adipose and other tissues and leaves the body only rather slowly (t1/2 ~ 70 d). Red-brown skin pigmentation is an unwanted effect, particularly in fair-skinned patients.
Whereas caffeine (1,3,7-trimethylxanthine) predominantly stimulates the CNS and constricts cerebral blood vessels, theophylline (1,3-dimethylxanthine) possesses additional marked bronchodilator, cardiostimulant, vasorelaxant, and diuretic actions.

 

Its poor absorption (N.B.quaternary N; absorption rate <10%) necessitates parenteral administration. Because the therapeutic effect is usually weak, a potent analgesic is given concurrently, e.g., the opioid meperidine. Note that some spasms of intestinal musculature can be effectively relieved by organic nitrates (in biliary colic) or by nifedipine (esophageal hypertension and achalasia).
Prescription ODT products initially were developed to overcome the difficulty in swallowing conventional tablets among pediatric, geriatric, and psychiatric patients with dysphagia. Today, ODTs are more widely available as OTC products for the treatment of allergies, cold, and flu symptoms. The target population has expanded to those who want convenient dosing anywhere, anytime, without water.